Injectable collagen Implant is composed of purified bovine dermal collagen emulsified in saline and lidocaine(0.3%) base, and has been promoted for correction of soft tissue contour defects.
Although collagen is a relatively nontoxic, nonimmunologic and biologically nonreactive biomaterial, some side reactions have been reported.
We report herein a case of cutaneous side reaction to collage implantation in a 38-year-old female. The patient presented with pruritic, irritating, multiple, erythematous nodules on both the temporal and interorbital area, which had been
observed
since
1 day after collagen(KOKEN ATELOCOLLA-GEN IMPLANT-Japan) implantation.
Histopathologic findings showed dense infiltration of acute and chronic inflammatory cells in the dermis, especially the perivascular and periadnexal area. (Kor J Dermatol 1994 ; 32(1) : 134~138)
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